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Trending
George Müller Feeds 10,000 Orphans on Prayer
Good News
— FROM 1836
The Bristol orphanages never ran an appeal, never took a loan, and never missed a meal — their founder simply prayed, and told the stories afterward.
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Gladys Aylward Leads 100 Orphans Over the Mountains
Good News
— FROM 1940
A London parlormaid rejected by every mission board walked nearly a hundred orphans across the mountains of war-torn China to safety.
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Orphaned Baby Kangaroo Rescued And Raised By Australian Family
Reporting
— Sep 22, 2024
Maggie, 7, with the kangaroo named Star. TIFFANY BANTON VIA SWNS. “> A woman has been hand-raising an orphaned baby kangaroo after rescuing her from the pouch of her dead mother. Tiffany Banton, 33, found the mother…
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What Children in One Orphanage Are Facing During the War in Ukraine
Reporting
— Mar 10, 2022
Many families are fleeing as the war in Ukraine continues, but many children are still left behind. A state-run orphanage in Lviv is currently housing many of these children, whose ages range from three to 16 years old…
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IJR
As California Burns Billions To Fail At High-Speed Rail, China Laid Enough Track To Circle America Three Times
Paris Apodaca · 6 min · 10h
LEO Pharma plans $435M Dersimelagon rights deal
x/leo-pharma
— Aug 18, 2026
LEO Pharma agreed to acquire worldwide rights to dersimelagon from Tanabe Pharma for up to $435 million, aiming to bring a late-stage oral MC1R agonist for EPP and XLP to market pending FDA approval. The deal reflects LEO’s strategy to grow its medical dermatology portfolio, backed by Phase 3 results, fast-track and orphan drug designations, and a planned 2027 launch if approved.
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Ranking
Most underrated cities in America
America's biggest cities hog all the spotlight, while dozens of smaller gems get overlooked despite great food, culture, and character. These underrated cities deserve recognition beyond the usual coastal favorites. Cast your vote and help crown the most underappreciated city in the country.
693 votes · 21 candidates
Zydus Lifesciences plans Phase III Desidustat trial sickle cell ICMR
x/united-states-of-america
— Jul 23, 2026
Zydus Lifesciences has received regulatory approval to initiate a 203-day Phase III trial of Desidustat for sickle cell disease in collaboration with ICMR, enrolling 164 patients to assess efficacy and safety of the oral tablet. The move follows successful Phase II results and US FDA Orphan Drug Designation, underscoring a public-private effort to address India's substantial SCD burden.
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Monopar Starts Rolling NDA for ALXN1840 Wilson Disease
x/united-states-food-and-drug-administration
— Jul 22, 2026
Monopar Therapeutics has begun a rolling submission of a New Drug Application with the FDA for ALXN1840 to treat Wilson disease, with the first completed sections already filed under a rolling NDA process. The first-in-class albumin tripartite complex activator carries Fast Track, Orphan Drug, and Rare Pediatric Disease designations and aims to become the first novel-mechanism therapy approved for Wilson disease in decades.
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Cadrenal Launches Cardiac Acute Care Franchise, Seeks Partners
Business
— Jul 21, 2026
Cadrenal Therapeutics has reorganized its clinical portfolio into a Cardiac Acute Critical Care Franchise and is launching a structured process to secure strategic out-licensing, portfolio monetization, or commercial co-development partnerships for its late-stage assets, including CAD-1005, frunexian, and tecarfarin. The move aims to maximize asset value through a partnership-driven model, supported by Phase 2 data showing more than a 25% reduction in thrombotic events and by orphan drug designations, with exploration of expanded indications such as Kawasaki disease in pediatrics and broader cardiorenal applications.
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Bloody Toddler Found Orphaned After Parade Shooting Takes Both Parents: GoFundMe Raises $2.4 Million
Reporting
— Jul 7, 2022
After the shooting that took place at the Highland Park Parade earlier this week, people have lost friends, family and loved ones — but few lost as much as Aiden McCarthy. Aiden, just 2 years old, was attending Monday’s…
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On X · @AKEndfield
Arknights: Endfield Official Account Drops Typhoeus Operator Story Trailer
The official @AKEndfield account posted a cinematic operator story video for the character Typhoeus (“Child of Samivegr”), highlighting her resilience against harsh wind and snow in a snowy environment. The ~2.5-minute trailer showcases animation, music, and character moments (including a snow angel). It is trending in the Arknights/Endfield gacha community due to fresh character lore/content, strong visual/audio praise, and an attached giveaway for Amazon gift cards and Typhoeus acrylic standees.
415 likes · 24m
Sweet Elderly Dog Adopts Third Set of Orphaned Ducklings: 'He Took to His Role Like a Duck to Water'
Reporting
— Jul 6, 2022
Labrador retrievers are known for their affinity for waterfowl — but generally it’s in a sporting sense as working dogs are bred to work alongside hunters, finding and returning downed fowl. But Fred doesn’t know about…
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Host Says He’s Haunted From Daring Elon Musk to Buy Twitter 4 Years Ago – Now the Takeover Is Complete
Opinion
— Apr 27, 2022
There is a quote often attributed to John F. Kennedy, but it is unclear who really said it first: “Victory has a thousand fathers, defeat is an orphan.” Many people want to claim they initiated a success after the fact…
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VS Battle
Physical Books vs E-Readers
Paper's soul versus the paperless suitcase.
Physical Books vs E-Readers · 145 votes — pick a side