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Novartis Phase 3 Pelacarsen Trial Misses Cardiovascular Endpoint
x/novartis
— 1d
Novartis reported that the Phase III Lp(a)HORIZON trial did not meet its primary endpoint, showing that lowering Lp(a) with pelacarsen reduced levels but did not significantly reduce cardiovascular events in approximately 8,000 patients on guideline-directed therapy; the company said full data will be presented at a future medical congress. Meanwhile, Royalty Pharma outlined its financial stance on the pelacarsen investment, noting the trial’s failure won’t derail its recovery of invested funds and that royalties on Spinraza remain a key part of its portfolio as it pursues its 2030 receipts target, with Ionis royalties potentially reverting after a defined cap. The developments reflect a broader scientific and market reevaluation of Lp(a)-targeted therapies and their commercial prospects.
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Jared Kim
Wonder how many other Lp(a) drugs in the pipeline just got a lot riskier to fund after this readout.
Guardant Health faces $245M patent verdict
x/university-of-washington
— Aug 24, 2026
A Delaware federal judge upheld a November 2023 verdict that Guardant Health willfully infringed TwinStrand Biosciences and the University of Washington patents for Duplex Sequencing, ordering Guardant to pay more than $245.2 million, including damages, supplemental damages, accrued royalties, and interest, and to continue paying a 6% royalty on 11 products that represented about 90% of revenue through March 2033 with quarterly accounting. The ruling confirms patent validity and imposes ongoing royalty obligations through the patent expiry, with Guardant facing further financial exposure as interest continues to accrue.
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Roche seals $1.53B Simcere trispecific deal
x/simcere-pharmaceutical
— 4d
Roche agreed to pay $75 million upfront to acquire exclusive global rights to SIM0660, a preclinical trispecific antibody from Simcere Zaiming that targets CD79a, CD19 and CD3, with total potential payments up to $1.53 billion and tiered royalties up to double digits. The therapy is designed to trigger T-cell–mediated killing across B-cell–mediated diseases, including autoimmune conditions, highlighting a growing collaboration between Roche and a Chinese biotech.
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Maya Lindstrom
Chinese biotech deals with big pharma keep growing, Simcere Zaiming landing this shows their pipeline is getting real attention.
Video
— YouTube
MISTRIAL: MA v. Lindsay Clancy - Day 28 | Accused Killer Mom Trial
COURT TV · 3.7M views · Sep 4, 2026
8:21:43
Norsemont Plans Restatement of 2025, 2026 Financials
Finance
— Aug 29, 2026
Norsemont Mining plans restatements of its 2025 annual and 2026 Q1 financials to reclassify convertible debentures and related derivative liabilities from non-current to current, increasing current liabilities by about $15.2 million at 2025-end and $22.9 million at March 31, 2026, and to include royalty disclosures. Management says the restatements affect presentation and disclosures rather than total liabilities, equity, losses or cash flows, with the 2025 debentures issued in December 2025 on a three-year maturity.
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IJR
Mexico Remains Silent as Cartels Extort, Kill Innocent Businessmen in Border State
Cartel Chronicles · 3 min · 8h
Chinese Vaccine Giants Paid Numerous Royalties To Fauci’s Former Agency, Records Show
Reporting
— Jun 5, 2024
Two Chinese vaccine manufacturers were among the most frequent payers of royalties to Dr. Anthony Fauci’s former agency during the 2022 and 2023 fiscal years, documents obtained by Open The Books show. Researchers from…
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Ranking
Most underrated cities in America
America's biggest cities hog all the spotlight, while dozens of smaller gems get overlooked despite great food, culture, and character. These underrated cities deserve recognition beyond the usual coastal favorites. Cast your vote and help crown the most underappreciated city in the country.
693 votes · 21 candidates
Hanmi Genentech obesity drug deal worth $2.3B reported
x/genentech
— Aug 24, 2026
Hanmi Pharmaceutical has signed an exclusive, worldwide license with Genentech for HM17321, a long-acting UCN2 analog aimed at obesity that promises weight loss with muscle preservation, with Genentech taking over development from Phase 2 onward outside Korea. The deal could reach about $2.3 billion, including a $190 million upfront, up to $2.1 billion in milestones, and future royalties, subject to U.S. antitrust clearance and successful clinical progression.
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‘She Was a Superstar’: Kelce Brothers Talk of Meeting Princess Charlotte, Prince William
Reporting
— Jun 26, 2024
When you put superstar and Taylor Swift concert in the same sentence, one automatically thinks of the megastar. That is unless there’s royalty present. “I got to say Prince William was fantastic, but the highlight was…
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Jasmine Crockett Is Apparently A Terrible Boss Who Makes Staffers Treat Her Like Royalty
x/jasmine-crockett
— Aug 7, 2025
Democratic Texas Rep. Jasmine Crockett’s aides have alleged that she “terrorizes” her staff and rarely shows up to the office unless she is in front of a camera. Crockett, who has a history of contentious behavior…
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Queen Elizabeth Makes Monumental Moving Decision After 70-Year Reign
Reporting
— Mar 9, 2022
While English royalty and Buckingham Palace have basically become synonymous, Queen Elizabeth has made a break with tradition to move in to one of her other well-known residences. While the “downgrade” from palace to…
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On X · @cortis_jp
CORTIS Japan Official Shares New Photos from 2026 “Put Your Phone Down” Tour
The @cortis_jp account posted fresh stage and group photos from the Japan leg of CORTIS’s 2026 world tour titled “PUT YOUR PHONE DOWN.” The post quickly gained thousands of likes and views as fans celebrated the end of the Japan shows, praised member looks and performances, and marked it as a milestone.
3,706 likes · 2m
Radio Royalties Fight Explodes on Capitol Hill
x/gene-simmons
— Dec 10, 2025
Gene Simmons arrived on Capitol Hill this week with a message he made impossible to ignore. According to PEOPLE , the 76-year-old KISS bassist took a seat before a Senate subcommittee on Tuesday and launched into an…
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Video
— YouTube
Mystery Ghost Ball in Wrigley's Ivy...🤔💀
Dugout Daze · 22.4M views · Aug 30, 2026
0:22
Prince Harry Has Considered US Citizenship
Reporting
— Feb 16, 2024
He may be British royalty, but Price Harry as considered becoming a U.S. citizen. The 39-year-old Duke of Sussex was asked by “ Good Morning America’s ” Will Reeve about life in America. The interview aired Friday…
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VS Battle
Soccer vs American Football
The world's game versus America's obsession — simplicity against spectacle.
Soccer vs American Football · 146 votes — pick a side
Moderna Pays Out $400 Million in Vaccine ‘Royalties’ Through Deal Inked Under Fauci
Reporting
— Mar 6, 2023
Drugmaker Moderna last week announced it had paid out $400 million to settle a dispute over the company’s use of federally funded research at two universities that led to the development of a technique used in its…
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Conservatives Rally Behind Radio Royalty Bill as Gene Simmons Prepares to Testify
x/gene-simmons
— Dec 8, 2025
A diverse bloc of conservative organizations is pressing congressional leaders to back a sweeping change to U.S. copyright law, just hours before rock icon Gene Simmons is slated to testify before the Senate Judiciary…
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Prince Harry Takes Jab at US for Electing Trump ‘King’
x/donald-john-trump
— Dec 4, 2025
When Prince Harry talks about royalty, one may assume he knows what he is talking about. But the real-life prince took time to make fun of Americans for electing President Donald Trump as “king.” Prince Harry made a…
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Daily Caller News Foundation
Cheap Chinese ‘Surveillance Machines’ Cannot Flood US Car Market At All Costs
When China was granted most favored nation status in 1997 and allowed into the World Trade Organization in 2001, the American people were promised such moves would lead to China becoming more democratic and peaceful, provide protections against theft of intellectual property, result in America manufacturing and exporting more goods to China, and there would be no loss of domestic manufacturing. Of
12h · 4 reads
Sixteen Critically Endangered Tortoise Hatchlings Make Debut at Philadelphia Zoo
x/philadelphia-zoo
— Aug 20, 2025
The Philadelphia Zoo just welcomed a new generation of slow-moving royalty — and gave them the red carpet treatment. Sixteen critically endangered western Santa Cruz tortoises made their public debut Wednesday in a rare…
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Quiz
Which of your friends survives the apocalypse?
Name the group and the AI ranks every one of them — who leads, who thrives, who trips in the first act. Private until you share it.
3 min · today's quiz
Amaal Mallik accuses Tanishk Bagchi of plagiarism
Entertainment
— Jul 23, 2026
Amaal Mallik publicly accuses Tanishk Bagchi of stealing songs, taking credit for Saiyaara, and using paid PR, while also hinting at sexual harassment; the dispute covers royalties and credit, with Bagchi and YRF defending the official payments. The controversy unfolds across multiple posts and reports, reinforcing a bitter feud over originality and industry practices.
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PolyPid Secures $320M D-PLEX100 Deal in U.S., Canada
Business
— Jul 21, 2026
PolyPid inked an exclusive U.S. and Canada commercialization deal with Azurity for D-PLEX100 to prevent surgical site infections, unlocking $15 million upfront, another $15 million upon FDA NDA acceptance, and up to about $300 million in additional milestones, with royalties mid-teen to mid-twenties and a U.S. launch aimed for Q1 2027. The agreement follows positive Phase 3 SHIELD II results and FDA Breakthrough Therapy Designation, with PolyPid retaining non-U.S. rights and manufacturing while Azurity funds clinical development for potential label expansions.
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Video
— YouTube
LISA - SaWaDiKa (Official Music Video)
LISAOfficialVEVO · 102.7M views · Sep 4, 2026
3:07